January 24, 2019

BRCA gene mutation 'doesn't affect breast cancer survival'

13 January 2018, 06:13 | Randall Craig

Many women uninformed about breast cancer surgery options

Having a mutated BRCA gene- as famously carried by Angelina Jolie- dramatically increases the chance a woman will develop breast cancer in her lifetime from 12 per cent to 90 per cent

This is also the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a BRCA gene mutation.

On Thursday, research led by the University of Southampton concluded that BRCA-mutated breast cancer is no more risky or aggressive than any other form of the disease.

Having a mutated BRCA gene - as famously carried by - dramatically increases the chance a woman will develop breast cancer in her lifetime, from 12 per cent to 90 per cent.

But faults in these genes raise the risk of developing breast and ovarian cancers, and a higher proportion of women who are aged under 40 when they are diagnosed have these faulty genes compared to older patients.

It suggests that although women diagnosed with breast cancer at a young age tend to have a poorer outlook, those who have BRCA gene faults aren't less likely to survive.

The agency said its approval was based on a randomized clinical trial of more than 300 advanced breast cancer patients with BRCA 1 or BRCA 2 mutations.

The PARP inhibitor is now available to patients with deleterious or suspected germline BRCA-mutated (bBRCAm), human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) who have been previously treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting. The hope is that by blocking the fix of cancer cells, the cells will die and slow or stop tumor growth, the FDA said in a news release Friday.

A study of nearly 3,000 British women found that preventative surgery - like a double mastectomy - straight after being diagnosed with this type of breast cancer did not improve survival over 10 years.

BRCA has been dubbed the "Angelina Jolie gene", after the actress revealed she underwent surgery on learning she had an up to 87% chance of developing breast cancer. "Our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment".

'Decisions about timing of additional surgery to reduce future cancer risks should take into account patient prognosis after their first cancer, and their personal preferences'. Overall, 96 percent of the 678 deaths were due to breast cancer after a median follow-up of 8.2 years. Most had chemotherapy, half has what's called breast-conserving surgery instead of a complete mastectomy, the other half had a full mastectomy and a very few did not have any surgery. A person's cancer risk can vary a lot depending on which mutation they have. It means that they can take time to discuss whether radical breast surgery is the right choice for them as part of a longer-term risk-reducing strategy.

Eccles, MD, University of Southampton and University Hospital Southampton NHS Foundation Trust, United Kingdom, and colleagues looked at survival following treatment for the initial breast cancer diagnosed only.

"It can be hard for some patients to decide whether or not to have risk-reducing surgery, typically double mastectomies and removal of ovaries".

Other News

Trending Now

China says will not attend Vancouver meeting on North…
He also said the meeting does not involve all the key countries related to the North Korean nuclear issue. The so-called Vancouver Group is formed by the countries that fought in the 1950-53 Korean War.

Dark Souls Comes to Switch in Dark Souls: Remastered
The most recent game in the series to be released was " Dark Souls III" in 2016. A Dark Souls Trilogy box has been announced for PlayStation 4 in Japan.

US Judge Blocks Trump Move to End DACA Program
That's according to three people who were briefed on the conversation but weren't authorized to describe it publicly. And at another point, said he was willing to let Congress handle the details and would sign the bill they sent him.

Trump rep, former porn star deny 'hush money' claims
Cohen also added that Trump "once again vehemently denies" the interaction, but stayed noticeably tightlipped about the $130K. She privately spoke about a consensual encounter she had with Trump in 2006 at a celebrity golf tournament in Lake Tahoe.

China's gas imports jump to record high as winter weather bites
In December, China's exports jumped 10.9% from a year ago to $231.8 billion, down from a 12.3% pace in the previous month. That left the country with a trade surplus of $54 billion for the month, the highest since January 2016.

Parents of 3-Year-Old Are Indicted in Her Death
In a second interview about two weeks after Sherin went missing, the father gave a different account. If Wesley is convicted of capital murder, he could face life in prison or the death penalty.

India thrash Pakistan by 7 wickets in Blind Cricket World Cup
The plate tournament will run simultaneously but end with the final at the Bert Sutcliffe Oval in Christchurch on January 28. India's refusal to travel to Pakistan for the World Cup forced the organisers to shift all their matches to UAE.

Ventura County flu deaths rise again; public health officials urge vaccination
Washoe County health officials have confirmed two more flu-related deaths. In H3N2-dominant seasons the flu vaccine is typically not as effective.

NFL Divisional Round Odds: Falcons, Steelers highlight favorites
Prior to that, they averaged 31.1 points and 390.4 yards of offense per game , good for the best and the third-best in the league. If the Eagles are having trouble moving the ball Saturday night, the Falcons could find themselves in the same position.

Josh Donaldson Sets MLB Salary Arbitration Record at $23 Million
Not signing the 32-year-old to a long-term extension will allow him to walk in free agency this winter. Donaldson has a.285 batting average with 111 home runs and 300 RBIs over three seasons in Toronto.