profishingrods.com
profishingrods.com July 17, 2018


Amgen Wins Race To Migraine Prevention Drug - Lilly, Teva, Alder Trail

18 May 2018, 04:46 | Randall Craig

The FDA has approved the first drug to prevent migraines

Drug To Prevent Chronic Migraine Gets FDA Approval

Aimovig (erenumab) has been cleared by the USA regulator as a once-monthly, self-injected preventive treatment for migraines based on data from three clinical trials which showed the drug was able to reduce the number of migraine days in a month compared to placebo. Professionals the FDA approved a prophylactic, which affects the peptide calcitonin, a molecule which is involved in the formation of headaches.

"The FDA approval of Aimovig demonstrates Novartis commitment to bringing meaningful new medicines to patients with complex neurologic diseases, like migraine", said Paul Hudson, who heads Novartis pharma division said in the company's press release.

"Cluster headache can be hard to evaluate in clinical studies, which has contributed to few available treatment options for clusterheadache, often considered the most severe pain one can experience", noted Christi Shaw, president of Lilly Bio-Medicines, in the release. These are most common among people who are in their 30s, especially the women, and can stay for long hours or in worst cases, even days.

Aimovig is produced by Amgen and Novartis, and it's expected to be available within a week, according to The New York Times.




The first study included 955 participants with a history of episodic migraine and compared Aimovig to placebo. "Importantly, in clinical trials, Aimovig patients were able to start and stay on therapy - with a discontinuation rate of 2% percent due to adverse events - and experienced sustained migraine prevention".

Teva's fremanezumab and Eli Lilly and Co.'s galcanezumab are both awaiting a decision, and Alder's eptinezumab NDA is expected later this year. But it's known well among the migraine-afflicted that there is not medicine to treat or prevent these severely debilitating episodes that some patients can see coming.

Amgen and Novartis are committed to supporting the migraine community and to helping appropriate patients with affordable access to Aimovig. The company found in two studies that patients on the drug had between a 3.6 and 4-day reduction in migraine days per month (to be eligible, patients had to have between 4 and 14 migraine days per month). Atogepant, the company's preventative treatment, is now in phase 2 clinical trials. However, most of the migraine patients avoid using these treatments as they do not help them get enough relief or tend to cause severe side effects.

The third study evaluated 667 patients with a history of chronic migraine and compared Aimovig to placebo.



Other News

Trending Now

U.S. may impose sanctions against companies engaged in Nord Stream 2 construction
The US opposes the project because it will increase Europe's reliance on Russian Federation for gas supplies. The only shareholder of the latter is Gazprom.

Facebook's Zuckerberg bound for Brussels
This after revelations that political consultancy Cambridge Analytica improperly accessed details of millions of Facebook users. He might get tougher questions in Brussels, where an assertive new European data protection law comes into effect on May 25.

French-led pushback against Iran sanctions may help India
Despite the bloc's unified push against the sanctions, some companies are already backing out of business with Iran . While walking out of the deal, Trump also reinstated sanctions on Iran as well as anyone dealing with Iran .

United Airlines will increase nonstop service between Newark and Sarasota
But Frontier said it will monitor the routes to determine whether to extend them to year-round service. The new route includes an 8:16 p.m. departure from Cleveland, arriving in San Antonio at 10:21 p.m.

North Korea threatens to scrap Trump summit over military drills
North Korea's warning came hours after it abruptly canceled a high-level meeting with South Korea to protest U.S. The military drills called "Max Thunder" are taking place between the United States and South Korea air forces .

Where Was Nakia During Avengers: Infinity War? Here's What Marvel Says
It means that there is a huge possibility that some of the original Avengers could end their legacy on the next Avengers movie. Everyone who continues to support these characters and the Marvel Universe, you are the best. " We gave cheers...a few times".

Bill Gates Just (Politely) Called Trump a Lecherous Fool
Gates' 22-year-old daughter Jennifer , an award-winning equestrian, had taken part at an event organized by Trump in Florida. Gates said he saw him at another meeting at Trump Tower about energy, health, and education, HIV vaccine, things like that.

PayPal in talks for $2.2bn takeover of iZettle
The news came just after iZettle announced last week that it would list an IPO on the Nasdaq in Stockholm later this year. Upon closing, iZettle will become the European center of excellence for PayPal's in-store product and services offerings.

Guardiola's new Manchester City deal makes him Europe's highest-paid manager
Club chairman Khaldoon Al Mubarak is delighted to have tied the Spaniard down to a new long-term contract. It's never happened before in the Premier League and to have three digits of points is unbelievable ".

White House Weighs in on Laurel vs. Yanny Debate: 'I Hear Covfefe'
But there are also plenty of White House staffs who only hear Yanny, including strategic-communications director Mercedes Schlapp. The White House has published on Twitter a video showing staffers taking on the key question of the week.