Three Chilean Bishops have presented their resignations letters to Pope Francis over allegation of sexual misconduct.
Karadima was suspended for life by the Vatican over the allegations of child molestation.
"A new day has begun in Chile's Catholic Church!" tweeted Juan Carlos Cruz, the abuse survivor who denounced Barros for years and pressed for the Vatican to take action.
He also made a decision to host three Chilean sex abuse survivors at his home in the Vatican so he could apologise to them personally and hear their recommendations for change.
In addition to Barros, the communique said Francis accepted the resignation of Archbishop Cristian Caro Cordero of Puerto Montt, naming Fr. Ricardo Basilio Morales Galindo, provincial for the Order of Mercy in Chile as apostolic administrator.
Both men are 75, the age when such resignations are required to be submitted to the pope.
Francis angered anti-abuse activists and others in Chile when, during a trip to the South American nation in January, he told an interviewer that the accusations against Barros lacked evidence and amounted to "calumnies".
In an unprecedented move, all Chile's 34 bishops offered to resign last month after attending a crisis meeting with Francis over allegations that sexual abuse in the country's Catholic church had been covered up.
The Pope's move comes after he received two groups of victims of Fernando Karadima at the Vatican.
Bishop Barros was accused of covering up sexual abuse committed by a priest in the 1980s and 1990s.
It qualifies the removal of certain prelates from their roles as necessary but "insufficient", calling for "the roots" that allowed for such abuse within an "elitist and authoritarian" Chilean church to be examined.
Pope Francis will join the rally for the final two days, August 25-26, presiding over the final Mass in Dublin.
"I can not help but express the pain and shame, shame that I feel over the irreparable harm caused to children by church ministers", Francis said at La Moneda government palace in Santiago.
They questioned Barros' suitability to lead given he had been a top lieutenant of Chile's most notorious predator priest and had been accused by victims of witnessing and ignoring their abuse.
Archbishop Charles Scicluna of Malta and Father Jordi Bertomeu Farnos were set to visit the Diocese of Osorno "with the aim of advancing the process of reparation and healing of abuse victims", the Vatican said in a statement on May 31.
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