profishingrods.com
profishingrods.com September 19, 2018


HIV vaccine delivers promising results in human tests

10 July 2018, 04:55 | Randall Craig

HIV Vaccine Could Potentially Provide Immunity

Scientists announced that a trial drug against the AIDS vaccine has yielded encouraging results and has advanced to the next phase of the pre-approval trial process

Medical science has cured many diseases and now a new study reveals HIV vaccine that has the potential to protect people around the world as the treatment has shown promising results.

Meant to provide broad protection from the many strains of HIV that are prevalent worldwide, the "mosaic" vaccine contains a patchwork of genetic sequences found among various HIV strains. All of them were aged 18 to 50 with healthy medical records and no HIV.

To address these methodological issues, the scientists evaluated the leading mosaic adenovirus serotype 26 (Ad26)-based HIV-1 vaccine candidates in parallel clinical and pre-clinical studies to identify the optimal HIV vaccine regimen to advance into clinical efficacy trials. A vaccine would not only be more manageable, but also more effective. All the participants went through a random, double blind kind of trial which is being referred to as "mosaic" vaccine which is basically pieces of various HIV viruses, combined together to induce immune responses against the HIV strains. According to the study authors, the vaccine produced "robust (high levels of) immune responses" in the participants.

Near about 1.8 million people get affected with HIV virus per year and almost thirty-seven million individuals are living with the virus globally. A safe and effective preventative vaccine is urgently needed to curb the HIV pandemic.

The Ad26/Ad26 plus gp140 vaccine candidate induced the greatest immune responses in humans and also provided the best protection in monkeys, resulting in complete protection against infection of SHIV, a virus similar to HIV that infects monkeys, in two-thirds of the vaccinated animals.

"These results represent an important milestone", Barouch said when speaking with BBC News.

"Based on these data, the mosaic Ad26/Env HIV-1 vaccine has been advanced into a phase 2b clinical efficacy study to determine whether this vaccine will prevent HIV infection in humans in southern Africa". "Obviously, the search for an HIV vaccine is very elusive", said Dr. Carlos del Rio, who was not involved with the study but has done similar research as the co-principal investigator of the Emory-CDC HIV Clinical Trials Unit. The 2 boost vaccinations used various combinations of Adv.Mos.HIV or Modified Vaccina Ankara, with or without 2 different doses of clade C HIV gp 140 envelope protein containing an aluminum adjuvant.




In the near four decades since the start of the Aids crisis, this is only the fifth experimental vaccine that has progressed to a stage where it can be tested on humans.

Dr Brady added that in the meantime there were already tools that were effective for preventing the disease from spreading, such as contraception and treatments for HIV-positive people that prevent them from passing on the virus.

Buchbinder said that she hoped "to validate our non-human primate model to see if it works for humans and if we see the same correlates of protection".

3d rendered HIV Virus in Blood Stream in color background.

The research was funded by Janssen Vaccines & Prevention, the US National Institutes of Health, the Ragon Institute, the Henry M Jackson Foundation for the Advancement of Military Medicine, the US Department of Defense, and the International AIDS Vaccine Initiative.

More than 80% of people who received this version also showed positive signs for 2 other measures of immune response.



Other News

Trending Now

Russian Federation celebrates team's run despite World Cup exit
Sadly for Fox and soccer fans, there's a few days of World Cup silence until France take on Belgium on July 10 and then England v. The national team has been gaining followers and drawing increasing political attention from government leaders with every win.

India beats England in 3rd T20, wins series 2-1
The all-rounder was hit for 22 runs in his first over by Roy but he showed good composure to bounce back in his next three. Rohit duly reached his hundred, and Pandya provided the exclamation mark with a six off the fourth ball of the 19th over.

5 things to know about Amazon Prime day
The annual retail holiday, which has become the biggest shopping day outside of Black Friday , is only open to members. Amazon has a Hitachi 50-inch 4K LED TV on sale for $289.99 as its Deal of the Day.

Harry Kane says 'band of brothers' spirit is driving England on
Vardy is in talks over a new deal which will net him up to £150,000-a-week and Maguire will get the same, following a stunning World Cup campaign.

Donald Trump defends US position on baby formula
Russian Federation ultimately sponsored the resolution and the American delegation did not issue any threats to the country. The State Department declined to comment to the Times , saying it could not remark on private diplomatic discussions.

People possibly exposed to tuberculosis at Johns Hopkins
The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. Two percent are extensively drug-resistant, meaning they can resist almost every available antibiotic in modern use.

Daredevil Travis Pastrana replicates Evel Knievel's jumps
Pastrana ended the event by jumping into the fountain as hundreds of fans on the streets of Las Vegas cheered him on. Garbed in that ver ysame red, white and blue, Pastrana attempted three of of Knievel's most well-known jumps.

See Maisie Williams' bloody goodbye to 'Game of Thrones'
The final season Game of Thrones will consist of six episodes, rumoured to all be movie length. We guess we have to wait until 2019 to find out how Game of Thrones ends.

Starbucks to eliminate plastic straws from all stores
McDonald's said earlier this year that it would stop using plastic straws at all of its stores in the United Kingdom and Ireland. This would apply to its more than 28,000 company operated and licensed stores, the coffee giant announced on Monday (Jul 9).

Dead, 70 Injured in Turkish Train Derailment
According to reports, the train was travelling from Uzunkopru to Instanbul and came off the rails in the Tekirdag Corlu district. A passenger with hundreds on board has come off the rails in northwest Turkey killing 10 people and injuring scores of others .