He swept through the opening set in just 16 minutes, dropping just five points, before shifting down a gear to conserve petrol for what he expects to be a more arduous second week of the championships.
"It was tougher than the scoreline, " Williams said. "I always enjoy playing against him", said Nishikori, who has beaten the Serb just twice in 15 meetings. So it's really cool. Once more, the players went to a tiebreak.
"That sometimes there is a set like this against a player who is not the biggest server, it can happen". She is seeded 25th after missing last year's tournament while pregnant. In the women's draw it is being generated by a mix of old and young aspirants after the filleting of the top 10 which left only seventh seed Karolina Pliskova upright after six days.
Raonic fired 37 aces and 74 winners to defeat Mackenzie McDonald of the United States and reach the quarter-finals for the fourth time.
The Spaniard hit back immediately though and sealed victory on his third match point when Vesely served at 4-5. She beat the ninth-seeded Williams in the third round after coming from a break down in the third set.
Returning to Wimbledon on the back of a three-match run at Roland Garros - her comeback tournament after giving birth for the first time in September - the 2016 champion has swatted away her opposition for the cost of 24 games.
Having saved a host of break points, Mannarino eventually faltered at 5-5 and looked to be suffering from discomfort in his right groin as Federer held to love to open up a two-set lead.
Elsewhere in fourth round action, Dominika Cibulkova launched a scathing attack on Wimbledon's officials after a line call controversy marred her 6-4, 6-1 win against Taiwan's Hsieh Su-Wei.
Rafael Nadal on Monday reached the Wimbledon quarterfinals for the first time since 2011.
Nadal, who plays at a slower, more deliberate pace, had no trouble with 93rd-ranked Jiri Vesely either, dismissing him, 6-3, 6-3, 6-4, in less than two hours.
Nadal, a two-time champion at the All England Club, has yet to drop a set in this tournament. For the third time in the match, a set needed a tiebreak to separate the heavy-hitters.
Monfils and Anderson have yet to get to the quarterfinals at Wimbledon, although the French shotmaker may just be the slight favorite as he has a 5-0 winning record over the big South African.
Stefanos Tsitsipas can make history by becoming the first Greek player - man or woman - to reach a Grand Slam quarter-final if he beats USA ninth seed John Isner.
Out of 13 Rescued from Flooded Cave in Thailand
Authorities in northern Chiang Rai province began the unsafe mission to bring out the 12 boys and their coach earlier on Sunday. Narongsak said experts told him the new rain could shrink the unflooded space where the boys are sheltering to 108 square feet.
Why English soccer fans chant 'It's coming home'
On the albums chart British synth pop group Years & Years are on course to debut at number one with sophomore release Palo Santo. England reached the World Cup finals only once before, back in 1966 when they hosted and won the Fifa World Cup.
A guide to semi-finals
But if some critics of France have been silenced by superb performances, it had been a different story in Belgium until recently. Hazard said that his country will find it hard to beat France if Chelsea teammate N'Golo Kante "is at his best" for Les Bleus .
Antonio Conte returns to take Chelsea training
And the Spanish duo were both involved as Chelsea FC underwent their first pre-season training session on Sunday. Chelsea endured a rather frustrating season last term in the Premier League as they finished fifth on the table.
Europe dominate World Cup semi final spots
He succeeded Carlos Dunga in 2016 and guided Brazil to a comfortable World Cup qualification. The teams then traded two scores each before Ivan Rakitic calmly scored the winning penalty.
5 things to know about Amazon Prime day
The annual retail holiday, which has become the biggest shopping day outside of Black Friday , is only open to members. Amazon has a Hitachi 50-inch 4K LED TV on sale for $289.99 as its Deal of the Day.
Daredevil Travis Pastrana replicates Evel Knievel's jumps
Pastrana ended the event by jumping into the fountain as hundreds of fans on the streets of Las Vegas cheered him on. Garbed in that ver ysame red, white and blue, Pastrana attempted three of of Knievel's most well-known jumps.