With Internazionale drawing against Barcelona in the other fixture in Group B, Spurs not only have to beat Inter in three weeks but will nearly certainly need to achieve a better result than the Italian club in the final matchday - when Spurs travel to the Camp Nou.
But captain Harry Kane breathed fresh life into his side's European campaign by equalising in the 78th minute and then seeing an 89th-minute header deflect off PSV substitute Trent Sainsbury and trickle over the line.
Spurs host Serie A side Inter on November 28, before finishing the group stage at the Nou Camp on December 11.
You must go back to Pochettino's first season in charge to find a more generous side - that team's 12.9 shots faced per game marginally higher than this season's 12.6.
"The belief is still there, you know me, I am so optimistic".
Winks clocked up the full 90 minutes at Wembley on Tuesday as Tottenham overturned a one-goal deficit to emerge 2-1 winners by the end of the Champions League Group B clash.
"We cannot control everything in the game but we can do better with the ball".
While Tottenham are far from certain to make the last 16, they could at least allow themselves a huge sigh of relief after staving off elimination at the group stage for the second time in three seasons. However, in the Champions League, Spurs have struggled, allowing at least two goals in each of their first three games.
Iin the final moments of regular time, another Kane header took one deflection in the box off a PSV defender before deflecting again off Sainsbury - and beating the wrong-footed keeper.
"I'm so pleased [about tonight's win], with the effort after what was our fourth game in nine days".
'We never gave up.
PSV are decent and have some players that can do damage.
The 89th minute victor ended PSV's chances of progression from the group stage yet that didn't stop the Australian from owning the mistake and agreeing to a post-match interview with Optus Sport just minutes after the final whistle.
PSV boss Mark van Bommel hailed his team in defeat and criticised the Wembley pitch but refused to use it as an excuse.
First Muslim woman elected to House of Representatives
In 1995, they emigrated to the United States, initially settling in Arlington, Virginia and then moving to Minneapolis. She was joined shortly after on Tuesday night by Omar , who ran for the Democrats in Minnesota's fifth district.