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Ever Baby Born Following A Uterus Transplant From A Deceased Donor

06 December 2018, 01:49 | Randall Craig

Ever Baby Born Following A Uterus Transplant From A Deceased Donor

Doctors hold a baby girl born to a mother who received a uterus from a deceased donor in Brazil. A novel transplantation procedure may help more infertile women become pregnant

Researchers in Brazil released a groundbreaking study Tuesday on the first baby born to a woman with a transplanted uterus from a deceased donor.

Her baby girl was born via a caesarean section at 35 weeks and three days gestation, and transplanted uterus was removed during the c-section. They also note that it could potentially make uterus transplants more widely available, especially in countries that already regulate and distribute organ donations from deceased donors.

In the Brazilian case, the journal said the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome.

The transplant was performed September 20, 2016, and a fertilized embryo was implanted about seven months later. The organ was transplanted into a 32-year-old woman who had a disorder that left her without a uterus.

"Our results provide a proof-of-concept for a new option for women with uterine infertility", said Dani Ejzenberg, a doctor at the teaching hospital of the University of Sao Paulo.

Uterine transplants from living donors have occurred before.

The donated uterus was removed during the delivery, as is typical for such transplants - this way the patient doesn't have to keep taking the medications needed to avoid rejection.

Four years ago, a 36-year-old Swedish woman also successfully delivered a healthy child using IVF via a womb provided by an unrelated benefactor.




He said: "All in all, the research to be done in this field (whether from alive or deceased donors) should maximise the live birth rate, minimise the risks for the patients involved in the procedures (donor, recipient, and unborn child), and increase the availability of organs".

The world's first baby has been born via a uterus transplanted from a dead donor. Last year, doctors at Baylor University Medical Center in Dallas delivered the first USA baby to be carried in a transplanted uterus.

The surgical team had to connect the donor's uterus with the veins, arteries, ligaments, and vaginal canal of the recipient. "There is the potential for uterus transplantation becoming mainstream".

"The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population", said Ejzenberg, according to Reuters.

"Successful pregnancy, without evidence of any compromise in spite of the uterus (womb) being without oxygen for eight hours before transplant, was unique". "Infertility can have a devastating impact upon couples, particularly for women with absolute uterine factor infertility, for which there has been no effective treatment to date and - for some of these women, womb transplantation is the only way they can carry a pregnancy", stated Mr J Richard Smith, spokesperson for the Royal College of Obstetricians and Gynaecologists and Clinical Lead at Womb Transplant UK.

She stayed in intensive care for two days after the surgery and then spent six more on a specialised transplant ward.

The Brazilian researchers are planning two more uterus transplants as part of the study.

The group of women who would benefit from a uterus transplant is very small. Fifteen were fertilised, with 8 resulting in embryos that were subsequently preserved for later implantation.



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