Former Suits actress Meghan, 37, is estranged from her father following a string of high-profile incidents since she became engaged to Harry.
The Gravity star went on to directly reference the alleged handwritten letter, in which Meghan reportedly accused her dad Thomas of having "broken my heart into a million pieces" by telling falsehoods to the media.
Shortly before his daughter was due to Wednesday Harry, Thomas staged paparazzi photos of himself preparing for the wedding.
Mr. Markle this weekend shared "devastating" details of a letter sent to him by his daughter last summer with the Mail on Sunday.
They also expressed their concerns for Meghan and her unborn baby.
"I do want to say, they're just chasing Meghan Markle everywhere", Clooney told World Health Organization magazine during an interview in Los Angeles.
She later hits out at Thomas for attacking Prince Harry in public, despite him always being "patient, kind and understanding" to him, before then accusing her half-sister Samantha of creating a web of lies that Thomas has simply followed. He quickly dismissed the rumour, jokingly saying he has enough "s**t to deal with" as the father of twins.
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