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profishingrods.com April 19, 2019


Israeli Scientists Print World's First 3D Heart with Human Tissue

16 April 2019, 12:56 | Randall Craig

15 2019 at the University of Tel Aviv shows a 3D print of heart with human tissue

15 2019 at the University of Tel Aviv shows a 3D print of heart with human tissue

Describing their work in Advanced Science, the research team started by taking biopsies of fatty tissues from abdominal structures known as the omentum in both humans and pigs. Today, 3D printers not only make jewellery and toothbrushes but also football boots, racing-car parts, custom-designed cakes, human organs, houses, aeroplane parts and even more efficient lithium-ion batteries. While the Tel Aviv University (TAU) team's 3D-printed heart doesn't actually work yet, it is the closest anyone has ever come to artificially replicating one of our most complex and vital organs. Given the dire shortage of heart donors, the need to develop new approaches to regenerate the diseased heart is urgent.

In early 2017, a team of biomedical engineering researchers, led by the University of Minnesota created a laser 3D-bioprinted patch to address the issue and help heal the scarred heart tissue after a heart attack.

To do this, they separated the cellular material from the tissues and reprogrammed it to become pluripotent stem cells.

"The cells need to form a pumping ability; they can now contract, but we need them to work together", Dvir explained.

The world's first "printed heart" was made with actual human biological material, although only about the size of a rabbit's heart, making it too small for a human, researchers said in the Advanced Science report. The maturing process will take about a month, after which they will transplant them into animals such as rabbits and rats for testing. In the past, researchers could manage to print a heart with only simple tissues without vessels, but this time they produced an entire heart, complete with cells, blood vessels, ventricles and chambers.

Until now, 3D printing has only been used to produce simple tissues without blood vessels, including making the structure of a heart but without the necessary vascular elements to make it actually pump. The use of "native" human material was imperative to the successful creation of the tissues and organs, the team said.




It's not the first time 3D printing technology was used to print organs.

"The biocompatibility of engineered materials [was] crucial to eliminate the risks of implant rejection, which jeopardizes the success of such treatments", said Dr. Dvir. "Ideally, the biomaterial should possess the same biochemical, mechanical and topographical properties of the patient's own tissues".

The researchers are now planning on culturing the printed hearts in the lab and "teaching them to behave" like hearts, Prof.

This article has been republished from materials provided by Tel Aviv University American Friends.

"Maybe, in ten years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely", Dvir said in a press release published by Tel Aviv University.



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